Many patients ask why or why not they have received an instillation of Mitomycin C right after their Turbt. Below is the recommendation from the CUA guidelines on management on Non-Muscle Invasive Bladder Cancer.
Below is a summary:
Chemotherapy
Single immediate postoperative instillation
• Immediate postoperative instillation of a chemotherapeutic
agent is recommended for all patients with
NMIBC after TURBT (Grade B recommendation).
• The efficacy of the immediate postoperative instillation
is optimal when administered within 6 hours from the
time of TUR and significantly decreases if given beyond
24 hours (Level of Evidence 2).
• Patients with suspected bladder perforation or deep/
extensive resection should not receive an immediate
instillation (Grade C recommendation).
• For patients in whom treatment with BCG is planned,
the benefit of an immediate postoperative instillation of
chemotherapy is less clear (Grade D recommendation)
The entire guideline can be found at this link:
https://www.cua.org/themes/web/assets/files/guidelines/en/3320.pdf
All the best,
Jack