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I am 71 and diagnosed with a bladder cancer (TaG2) in December 2017. On and off, I still try to find out what could have been the toxin which had caused BC. I know that I should focus on healing my BC rather than looking for the cause. But, I think it will help if I know what had contributed. For example, I may be able to reduce recurrence. I never smoked, did not work in industries which are mentioned as a risk factor for causing a BC. I understand that my age consequently with weakening immune system failed to kill BC cells. I understand that with my age, my bladder had been exposed to BC causing toxin for many year. I do not how many years was my BC with 2 cm in making. I do not know when it started. The only toxin I can think of is the medicines I have been taking over the years. I have a chronic asthma, so I have been inhaling asthma control medication for many years. Then about 10 years ago, I started taking Statin based cholesterol pill as my GP said I had 10% chance of heart attack with 10 years. So, I thought it could be my cholesterol pills which might have affected my BC. I am going to talk to my GP if I can be off Satin for a while.
Has anyone talked about Statin based cholesterol pills with your GP, Urologist, Oncologist?
Does our medical board have any recommendation?
Below are related researches done on the affect on Statin on BC. One New England Journal Paper by a Belgian doctor says “not to take Satin during BCG. Journal of Pharmacology and Phasmacovigilance paper in 2015 says Satins are associated with an increased risk of bladder cancer.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365486/
https://www.nejm.org/doi/full/10.1056/NEJMc062714
http://crescopublications.org/pdf/JPP/JPP-1-001.pdf
https://link.springer.com/article/10.1007/s10552-013-0159-3
Joey
Joe
Interesting research. Nobody has ever mentioned to me anything other than smoking as a possible cause for my own bladder cancer. I was a smoker for almost 30 years.
I suppose the statin drug and bladder cancer connection could be associative or co-incidental rather than causative … older people are the usual age group to have problems with cholesterol levels, and older people are also the usual age group to be diagnosed with bladder tumours.
I have been taking Lipitor, a statin drug, for many years (can’t actually recall when I started taking it) and was first diagnosed with bladder cancer 11 years ago.
I will be asking my GP about this next time I see him.
Hi Susan, I do not think much research is done on this subject, mainly because we all know that BC R&D funding had been very little compared to other cancers. In terms of smoking, because 50% of all cases of bladder cancer are found smokers (according to a 2011 study by NIH), we associate smoking to a cause of bladder cancer. In the same manner, if people on cholesterol drugs in the same age category are shown to be higher risk than people who are not on cholesterol drugs, then I think we can associate cholesterol drugs to a cause of bladder cancer.
I am especially interested in the research paper Journal of Pharmacology and Phasmacovigilance paper in 2015.
http://crescopublications.org/pdf/JPP/JPP-1-001.pdf
Table 4 of page 8 of 14 shows the result of their research.
Rosuvastatin, the cholesterol drug which I am taking, had 17,515 people prescribed with the drug during 2005-01 to 2013-07. In 48 month interval ( I do no understand what interval is), 65 people was diagnosed with BC before the drug was prescribed for the first time. On the other hand, 102 people were diagnosed with BC after the drug was prescribed. 102/65 = 1.57. If this number is 1, there is no association. The higher the number is the stronger association the drug is to BC.
Atrovasatin (Lapitor) : 14,359 people were prescribed with the drug in the same period. In 48 months, 65 was diagnosed with BC before the drug was prescribed for the first time. On the other hand, 86 people were diagnosed with BC after the drug was prescribed. 85/65 = 1.32
According to the paper, you have lesser risk than I because Lapitor has lesser association with BC than Rosuvastatin (Crestor). At least I should think of changing the drug if not possible to not to take it at all.
Joey
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I had a heart attack in August of 2014. Beside the blood pressure pills, and blood-thinners, I was also prescribed 80 MG of Atorvastatin per day by the heart specialist. I have always been pre-diabetes (since I was 27) and I took 40 MG of crestor from 1977 to 2007 when I was no longer considered pre-diabetes. Then in 2017 I was diagnosed with diabetes, but with a low carb, no added sugar diet turned this around with-in 8 weeks, back to pre-diabetes. The diet also allowed me to lose 18 lbs in just 8 weeks, which was expensive as I have to buy all new clothes (lol).
I am not sure what caused my bladder cancer, as I smoked for 42 years, and worked around dyes and chemicals for 25 years.
I have always believed that most cancers were caused by chemicals of some kind, whether in cigarettes, in the workplace, in pills, and even the food and water we consume.
JackHi Jack, thanks for sharing your experience.
Oh Boy, Jack, I do not know what to say. It sounds like you had been exposed to the mixed cocktail of all ingredients of so called risk factors. Yet, I understand you are BC free over 10 years with BCG treatments. I am very glad that BCG has worked for you.
I am also glad to know that your diet improved your sugar level much in just 8 weeks. We love to see before and after pictures someday. Since I became a BC patient, I also have become food conscience a bit more. I have lost also 3 kg since I was diagnosed with BC in December. But, I also think that the stress has contributed it too.
Well, Jack, please stay healthy and strong. We need you to continue to lead the BCC support group to fight against BC and support BC patients.
Joey
I have asked my urologust about this. He said every year a paper is published on one thing and another paper is published with an opposite view. He said its a gene. We couldnt or I should say I hesitated to pursue this topic further to take up his time. I am continuing taking my colesterol pill for now. But, I am drinking water hoping to wash its toxin down from my bladder although I do not know the right timing.
Joe
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