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This was a topic of discussion at our last support group meeting and it seems that in Calgary the uros mostly opt for chemo before an RC and only for cancer greater than T2 or a more rare type of cancer. A couple of members said that they started chemo but had to quit as the drug was compromising their kidney function. One gent found himself in this situation and he actually was only expected to survive for about a year. He is more than 3 years out from his RC and doing well other than coping with some infection in the stoma.
This is a personal opinion only, but I feel we have to be very careful when using these heavy duty drugs and less is more in some cases. People need to seek the advice of their docs and get a second opinion if necessary to make sure that this is the route that will give them the best possible outcome.